BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//CMSA - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:CMSA
X-ORIGINAL-URL:https://cmsa.fas.harvard.edu
X-WR-CALDESC:Events for CMSA
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/New_York
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20220313T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20221106T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20230312T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20231105T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20240310T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20241103T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20231012T130000
DTEND;TZID=America/New_York:20231012T140000
DTSTAMP:20260423T015633
CREATED:20240223T072135Z
LAST-MODIFIED:20240223T072135Z
UID:10002826-1697115600-1697119200@cmsa.fas.harvard.edu
SUMMARY:Contractility\, structure formation and fluctuations in active gels\, with and without molecular motors
DESCRIPTION:Active Matter Seminar\n\n\nSpeaker: Fred MacKintosh (Rice University) \nTitle: Contractility\, structure formation and fluctuations in active gels\, with and without molecular motors \nAbstract: Various processes in living cells depend on contractile forces that are often generated by myosin motors in concert with polar actin filaments. A textbook example of this is the actomyosin contractile ring that forms during cell division. Recent evidence\, however\, has begun to suggest alternate or redundant mechanisms that do not depend on myosin. Experiments on simplified\, reconstituted systems also point to contractility and structure formation in disordered\, apolar arrays of filaments. We propose a motor-free mechanism that can generate contraction in biopolymer networks without the need for motors such as myosin or polar filaments such as actin. This mechanism is based on active binding and unbinding of cross-linkers that breaks the principle of detailed balance\, together with the asymmetric force-extension response of semiflexible biopolymers. We discuss the resulting force-velocity relation and other implications of this\, as well as possible evidence for non-motor force generation.
URL:https://cmsa.fas.harvard.edu/event/am-101223/
LOCATION:CMSA Room G10\, CMSA\, 20 Garden Street\, Cambridge\, MA\, 02138\, United States
CATEGORIES:Active Matter Seminar
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/CMSA-Active-Matter-Seminar-10.12.23.png
END:VEVENT
END:VCALENDAR