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DTSTART;TZID=America/New_York:20231026T130000
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DTSTAMP:20260423T212255
CREATED:20240223T070828Z
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UID:10002825-1698325200-1698328800@cmsa.fas.harvard.edu
SUMMARY:Scaling behavior and control of nuclear wrinkling
DESCRIPTION:Active Matter Seminar\n\n\nSpeaker: Nicolas Romeo (UChicago) \nTitle: Scaling behavior and control of nuclear wrinkling \nAbstract: The cell nucleus is enveloped by a complex membrane\, whose wrinkling has been implicated in disease and cellular aging. The biophysical dynamics and spectral evolution of nuclear wrinkling during multicellular development remain poorly understood due to a lack of direct quantitative measurements. We characterize the onset and dynamics of nuclear wrinkling during egg development in the fruit fly when nurse cell nuclei increase in size and display stereotypical wrinkling behaviour. A spectral analysis of three-dimensional high-resolution live-imaging data from several hundred nuclei reveals a robust asymptotic power-law scaling of angular fluctuations consistent with renormalization and scaling predictions from a nonlinear elastic shell model. We further demonstrate that nuclear wrinkling can be reversed through osmotic shock and suppressed by microtubule disruption\, providing tunable physical and biological control parameters for probing the mechanical properties of the nuclear envelope\, highlighting in passing the importance of nonlinear response to biological robustness.
URL:https://cmsa.fas.harvard.edu/event/am-102623/
LOCATION:CMSA Room G10\, CMSA\, 20 Garden Street\, Cambridge\, MA\, 02138\, United States
CATEGORIES:Active Matter Seminar
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/CMSA-Active-Matter-Seminar-10.26.23.png
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