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DTSTART;TZID=America/New_York:20220210T130000
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DTSTAMP:20240304T083923Z
CREATED:20230824T172419Z
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UID:10001307-1644498000-1644503400@cmsa.fas.harvard.edu
SUMMARY:Active Matter Controlling Epithelial Dynamics
DESCRIPTION:Abstract: My lab is interested in the active and adaptive materials that underlie control of cell shape.  This has centered around understanding force transmission and sensing within the actin cytoskeleton.  I will first review our current understanding of the types of active matter that can be constructed by actin polymers.  I will then turn to our recent experiments to understand how Cell shape changes in epithelial tissue.  I will describe the two sources of active stresses within these tissues\, one driven by the cell cycle and controlling cell-cell stresses and the other controlled by cell-matrix signaling controlling motility.  I will then briefly describe how we are using optogenetics to locally control active stresses to reveal adaptive and force-sensitive mechanics of the cytoskeletal machinery. Hopefully\, I will convince you that recent experimental and theoretical advances make this a very promising time to study this quite complicated form of active matter.
URL:https://cmsa.fas.harvard.edu/event/active-matter-controlling-epithelial-dynamics/
LOCATION:MA
CATEGORIES:Active Matter Seminar
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/CMSA-Active-Matter-Seminar-02.10.22-1.png
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DTSTART;TZID=America/New_York:20220224T130000
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DTSTAMP:20240213T111913Z
CREATED:20230824T172910Z
LAST-MODIFIED:20240213T111913Z
UID:10001308-1645707600-1645713000@cmsa.fas.harvard.edu
SUMMARY:Taming Active Matter: from ordered topological defects to autonomous shells
DESCRIPTION:Abstract: The spontaneous emergence of collective flows is a generic property of active fluids and often leads to chaotic flow patterns characterized by swirls\, jets\, and topological\ndisclinations in their orientation field. I will first discuss two examples of these collective features helping us understand biological processes: (i) to explain the tortoise & hare story in bacterial competition: how motility of Pseudomonas aeruginosa bacteria leads to a slower invasion of bacteria colonies\, which are individually faster\, and\n(ii) how self-propelled defects lead to finding an unanticipated mechanism for cell death. \nI will then discuss various strategies to tame\, otherwise chaotic\, active flows\, showing how hydrodynamic screening of active flows can act as a robust way of controlling and guiding active particles into dynamically ordered coherent structures. I will also explain how combining hydrodynamics with topological constraints can lead to further control of exotic morphologies of active shells.
URL:https://cmsa.fas.harvard.edu/event/taming-active-matter-from-ordered-topological-defects-to-autonomous-shells/
LOCATION:MA
CATEGORIES:Active Matter Seminar
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/CMSA-Active-Matter-Seminar-02.24.22.png
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