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DTSTART;TZID=America/New_York:20220407T130000
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UID:10001310-1649336400-1649341560@cmsa.fas.harvard.edu
SUMMARY:Theories of branching morphogenesis
DESCRIPTION:Abstract:  The morphogenesis of branched tissues has been a subject of long-standing debate. Although much is known about the molecular pathways that control cell fate decisions\, it remains unclear how macroscopic features of branched organs\, including their size\, network topology and spatial pattern are encoded. Based on large-scale reconstructions of the mouse mammary gland and kidney\, we begin by showing that statistical features of the developing branched epithelium can be explained quantitatively by a local self-organizing principle based on a branching and annihilating random walk (BARW). In this model\, renewing tip-localized progenitors drive a serial process of ductal elongation and stochastic tip bifurcation that terminates when active tips encounter maturing ducts. Then\, based on reconstructions of the developing mouse salivary gland\, we propose a generalisation of BARW model in which tips arrested through steric interaction with proximate ducts reactivate their branching programme as constraints become alleviated through the expansion of the underlying mesenchyme. This inflationary branching-arresting random walk model offers a more general paradigm for branching morphogenesis when the ductal epithelium grows cooperatively with the tissue into which it expands.
URL:https://cmsa.fas.harvard.edu/event/theories-of-branching-morphogenesis/
LOCATION:MA
CATEGORIES:Active Matter Seminar
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/CMSA-Active-Matter-Seminar-04.07.22.png
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DTSTART;TZID=America/New_York:20220428T130000
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DTSTAMP:20240304T081149Z
CREATED:20230824T174429Z
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UID:10001813-1651150800-1651156200@cmsa.fas.harvard.edu
SUMMARY:Building active nematic and active polar liquids out of biological machines
DESCRIPTION:Speaker: Guillaume Duclos (Brandeis)\n\n\nTitle: Building active nematic and active polar liquids out of biological machines\nAbstract: Active matter describes out-of-equilibrium materials composed of motile building blocks that convert free energy into mechanical work. The continuous input of energy at the particle scale liberates these systems from the constraints of thermodynamic equilibrium\, leading to emergent collective behaviors not found in passive materials. In this talk\, I will describe our recent efforts to build simple active systems composed of purified proteins and identify generic emergent behaviors in active systems. I will first discuss two distinct activity-driven instabilities in suspensions of microtubules and molecular motors. Second\, I will describe a new model system for polar fluid whose collective dynamics are driven by the non-equilibrium turnover of actin filaments. Our results illustrate how biomimetic materials can serve as a platform for studying non-equilibrium statistical mechanics\, as well as shine light on the physical mechanisms that regulate self-organization in living matter. \n  \nVideo (Youtube)
URL:https://cmsa.fas.harvard.edu/event/building-active-nematic-and-active-polar-liquids-out-of-biological-machines/
LOCATION:Virtual
CATEGORIES:Active Matter Seminar
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/CMSA-Active-Matter-Seminar-04.28.22.png
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