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DTSTART;TZID=America/New_York:20210923T130000
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DTSTAMP:20240304T084241Z
CREATED:20240213T112248Z
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UID:10002493-1632402000-1632407400@cmsa.fas.harvard.edu
SUMMARY:The many phases of a cell
DESCRIPTION:Abstract: I will begin by introducing an emerging paradigm of cellular organization – the dynamic compartmentalization of biochemical pathways and molecules by phase separation into distinct and multi-phase condensates. Motivated by this\, I will discuss two largely orthogonal problems\, united by the theme of phase separation in multi-component and chemically active fluid mixtures. \n1. I will propose a theoretical model based on Random-Matrix Theory\, validated by phase-field simulations\, to characterizes the rich emergent dynamics\, compositions\, and steady-state properties that underlie multi-phase coexistence in fluid mixtures with many randomly interacting components. \n2. Motivated by puzzles in gene-regulation and nuclear organization\, I will propose a role for how liquid-like nuclear condensates can be organized and regulated by the active process of RNA synthesis (transcription) and RNA-protein coacervation. Here\, I will describe theory and simulations based on a Landau formalism and recent experimental results from collaborators.
URL:https://cmsa.fas.harvard.edu/event/the-many-phases-of-a-cell/
LOCATION:MA
CATEGORIES:Active Matter Seminar
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