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DTSTART;TZID=America/New_York:20220210T130000
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DTSTAMP:20240304T083923Z
CREATED:20230824T172419Z
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UID:10001307-1644498000-1644503400@cmsa.fas.harvard.edu
SUMMARY:Active Matter Controlling Epithelial Dynamics
DESCRIPTION:Abstract: My lab is interested in the active and adaptive materials that underlie control of cell shape.  This has centered around understanding force transmission and sensing within the actin cytoskeleton.  I will first review our current understanding of the types of active matter that can be constructed by actin polymers.  I will then turn to our recent experiments to understand how Cell shape changes in epithelial tissue.  I will describe the two sources of active stresses within these tissues\, one driven by the cell cycle and controlling cell-cell stresses and the other controlled by cell-matrix signaling controlling motility.  I will then briefly describe how we are using optogenetics to locally control active stresses to reveal adaptive and force-sensitive mechanics of the cytoskeletal machinery. Hopefully\, I will convince you that recent experimental and theoretical advances make this a very promising time to study this quite complicated form of active matter.
URL:https://cmsa.fas.harvard.edu/event/active-matter-controlling-epithelial-dynamics/
LOCATION:MA
CATEGORIES:Active Matter Seminar
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/CMSA-Active-Matter-Seminar-02.10.22-1.png
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