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DTSTART;TZID=America/New_York:20230511T130000
DTEND;TZID=America/New_York:20230511T140000
DTSTAMP:20240228T071614Z
CREATED:20230724T183239Z
LAST-MODIFIED:20240228T071614Z
UID:10002747-1683810000-1683813600@cmsa.fas.harvard.edu
SUMMARY:Insights from single cell lineage trees
DESCRIPTION:Active Matter Seminar\n\n\n\n\nSpeaker: Sahand Hormoz\, Harvard Medical School\, Dana-Farber Cancer Institute\n\n\n\n\nTitle: Insights from single cell lineage trees\n\n\n\n\nAbstract: In this talk\, I will discuss two recent projects from my lab that involve lineage trees of cells (the branching diagram that represents the ancestry and division history of individual cells). In the first project\, we reconstructed the lineage trees of individual cancer cells from the patterns of randomly occurring mutations in these cells. We then inferred the age at which the cancer mutation first occurred and the rate of expansion of the population of cancer cells within each patient. To our surprise\, we discovered that the cancer mutation occurs decades before diagnosis. For the second project\, we developed microfluidic ‘mother machines’ that allow us to observe mammalian cells dividing across tens of generations. Using our observations\, we calculated the correlation between the duration of cell cycle phases in pairs of cells\, as a function of their lineage distance. These correlations revealed many surprises that we are trying to understand using hidden Markov models on trees. For both projects\, I will discuss the mathematical challenges that we have faced and open problems related to inference from lineage trees.
URL:https://cmsa.fas.harvard.edu/event/am-51123/
CATEGORIES:Active Matter Seminar
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/CMSA-Active-Matter-Seminar-05.11.23.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230914T130000
DTEND;TZID=America/New_York:20230914T140000
DTSTAMP:20240223T111752Z
CREATED:20240223T111752Z
LAST-MODIFIED:20240223T111752Z
UID:10002860-1694696400-1694700000@cmsa.fas.harvard.edu
SUMMARY:Frustration-free states of cell fate networks: the case of the epithelial-mesenchymal transition
DESCRIPTION:Active Matter Seminar\n\n\nSpeaker: Herbert Levine (Northeastern)\n\nTitle: Frustration-free states of cell fate networks: the case of the epithelial-mesenchymal transition\n\nAbstract: Cell fate decisions are made by allowing external signals to govern the steady-state pattern adopted by networks of interacting regulatory factors governing transcription and translation. One of these decisions\, of importance for both developmental processes and for cancer metastasis\, is the epithelial-mesenchymal transition (EMT). In this talk\, we will argue that these biological networks have highly non-generic interaction structures such that they allow for phenotypic states with very low frustration\, i.e. where most interactions are satisfied. This property has important consequences for the allowed dynamics of these systems.
URL:https://cmsa.fas.harvard.edu/event/am-91423/
LOCATION:CMSA Room G10\, CMSA\, 20 Garden Street\, Cambridge\, MA\, 02138\, United States
CATEGORIES:Active Matter Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230928T130000
DTEND;TZID=America/New_York:20230928T140000
DTSTAMP:20240223T072654Z
CREATED:20240223T072654Z
LAST-MODIFIED:20240223T072654Z
UID:10002827-1695906000-1695909600@cmsa.fas.harvard.edu
SUMMARY:Strongly driven mixtures and membranes: Out of equilibrium surprises 
DESCRIPTION:Active Matter Seminar\n\n\nSpeaker: Max Lavrentovich\, Worcester State University \nTitle: Strongly driven mixtures and membranes: Out of equilibrium surprises \nAbstract: The more prosaic cousin of active matter\, driven inactive matter\, is still full of unexpected phenomena. I will discuss two projects involving two seemingly mundane systems\, a phase-separating colloidal mixture and a lipid membrane\, which demonstrate counterintuitive properties when driven out of equilibrium. We will see that the phase separating mixture\, when driven by a uniform force\, develops (in simulations) an intriguing pattern with a characteristic length scale set by the magnitude of the drive. We will look at some theoretical approaches to understanding the pattern formation and possible experimental realizations. The membrane\, when driven by an oscillatory electric field\, develops (in experiments) a long-lived metastable state with a decreased capacitance and increased dissipation. This state may have implications for neuronal processing and memory formation.
URL:https://cmsa.fas.harvard.edu/event/am-92823/
LOCATION:CMSA Room G10\, CMSA\, 20 Garden Street\, Cambridge\, MA\, 02138\, United States
CATEGORIES:Active Matter Seminar
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/CMSA-Active-Matter-Seminar-09.28.23.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20231012T130000
DTEND;TZID=America/New_York:20231012T140000
DTSTAMP:20240223T072135Z
CREATED:20240223T072135Z
LAST-MODIFIED:20240223T072135Z
UID:10002826-1697115600-1697119200@cmsa.fas.harvard.edu
SUMMARY:Contractility\, structure formation and fluctuations in active gels\, with and without molecular motors
DESCRIPTION:Active Matter Seminar\n\n\nSpeaker: Fred MacKintosh (Rice University) \nTitle: Contractility\, structure formation and fluctuations in active gels\, with and without molecular motors \nAbstract: Various processes in living cells depend on contractile forces that are often generated by myosin motors in concert with polar actin filaments. A textbook example of this is the actomyosin contractile ring that forms during cell division. Recent evidence\, however\, has begun to suggest alternate or redundant mechanisms that do not depend on myosin. Experiments on simplified\, reconstituted systems also point to contractility and structure formation in disordered\, apolar arrays of filaments. We propose a motor-free mechanism that can generate contraction in biopolymer networks without the need for motors such as myosin or polar filaments such as actin. This mechanism is based on active binding and unbinding of cross-linkers that breaks the principle of detailed balance\, together with the asymmetric force-extension response of semiflexible biopolymers. We discuss the resulting force-velocity relation and other implications of this\, as well as possible evidence for non-motor force generation.
URL:https://cmsa.fas.harvard.edu/event/am-101223/
LOCATION:CMSA Room G10\, CMSA\, 20 Garden Street\, Cambridge\, MA\, 02138\, United States
CATEGORIES:Active Matter Seminar
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/CMSA-Active-Matter-Seminar-10.12.23.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20231026T130000
DTEND;TZID=America/New_York:20231026T140000
DTSTAMP:20240223T070828Z
CREATED:20240223T070828Z
LAST-MODIFIED:20240223T070828Z
UID:10002825-1698325200-1698328800@cmsa.fas.harvard.edu
SUMMARY:Scaling behavior and control of nuclear wrinkling
DESCRIPTION:Active Matter Seminar\n\n\nSpeaker: Nicolas Romeo (UChicago) \nTitle: Scaling behavior and control of nuclear wrinkling \nAbstract: The cell nucleus is enveloped by a complex membrane\, whose wrinkling has been implicated in disease and cellular aging. The biophysical dynamics and spectral evolution of nuclear wrinkling during multicellular development remain poorly understood due to a lack of direct quantitative measurements. We characterize the onset and dynamics of nuclear wrinkling during egg development in the fruit fly when nurse cell nuclei increase in size and display stereotypical wrinkling behaviour. A spectral analysis of three-dimensional high-resolution live-imaging data from several hundred nuclei reveals a robust asymptotic power-law scaling of angular fluctuations consistent with renormalization and scaling predictions from a nonlinear elastic shell model. We further demonstrate that nuclear wrinkling can be reversed through osmotic shock and suppressed by microtubule disruption\, providing tunable physical and biological control parameters for probing the mechanical properties of the nuclear envelope\, highlighting in passing the importance of nonlinear response to biological robustness.
URL:https://cmsa.fas.harvard.edu/event/am-102623/
LOCATION:CMSA Room G10\, CMSA\, 20 Garden Street\, Cambridge\, MA\, 02138\, United States
CATEGORIES:Active Matter Seminar
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/CMSA-Active-Matter-Seminar-10.26.23.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20231109T130000
DTEND;TZID=America/New_York:20231109T140000
DTSTAMP:20240223T060824Z
CREATED:20240223T060824Z
LAST-MODIFIED:20240223T060824Z
UID:10002824-1699534800-1699538400@cmsa.fas.harvard.edu
SUMMARY:Nuclear chromodynamics: non-equilibrium phase transition in the nucleus of a living cell
DESCRIPTION:Active Matter Seminar\n\n\nSpeaker: Alexander Grosberg (NYU)\n\nTitle: Nuclear chromodynamics: non-equilibrium phase transition in the nucleus of a living cell \nAbstract: Nucleus of a living cell houses a cell genome – a polymer called chromatin\, which is a functional form of DNA.  It is very long\, e.g.\, 2 meters long for every human cell.  Nucleus is also an arena of incessant energy-driven activity.  Experiments show that chromatin undergoes large scale motions sustained over long times of order seconds.  In the talk\, after reviewing the phenomenology\, I will show how these flows may arise due to a phase transition in which chromatin-driving motors\, such as RNA polymerase\, form a polar (“ferromagnetic”) order controlled by hydrodynamic interactions.  The talk is based on the joint work with I.Eshghi and A.Zidovska.
URL:https://cmsa.fas.harvard.edu/event/am-11923/
LOCATION:CMSA Room G10\, CMSA\, 20 Garden Street\, Cambridge\, MA\, 02138\, United States
CATEGORIES:Active Matter Seminar
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/CMSA-Active-Matter-Seminar-11.09.23.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20231207T130000
DTEND;TZID=America/New_York:20231207T140000
DTSTAMP:20240223T055715Z
CREATED:20240223T055715Z
LAST-MODIFIED:20240223T055715Z
UID:10002823-1701954000-1701957600@cmsa.fas.harvard.edu
SUMMARY:Active structures and flows in living cells
DESCRIPTION:Active Matter Seminar\n\n\nSpeaker: Michael Shelley (Flatiron) \nTitle: Active structures and flows in living cells \nAbstract: Flows in the fluidic interior of living cells can serve biological function or act as signatures of how intracellular forces are exerted. I’ll discuss examples of each. One is understanding the emergence of cell-spanning vortical flows in large developing egg cells\, while the other arises in studying the nature of force transduction in single cell embryos moving towards their first cell division. Both involve the cytoskeleton\, that set of polymers\, cross-linkers\, and molecular motors that underlie much of the active mechanics within cells\, and has led to the development of new coarse-grained active matter models and novel instabilities.
URL:https://cmsa.fas.harvard.edu/event/am-12723/
LOCATION:CMSA Room G10\, CMSA\, 20 Garden Street\, Cambridge\, MA\, 02138\, United States
CATEGORIES:Active Matter Seminar
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/CMSA-Active-Matter-Seminar-12.07.23.docx-1.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240229T130000
DTEND;TZID=America/New_York:20240229T140000
DTSTAMP:20240226T155546Z
CREATED:20240222T194931Z
LAST-MODIFIED:20240226T155546Z
UID:10002812-1709211600-1709215200@cmsa.fas.harvard.edu
SUMMARY:Directed motion in active matter: Frictiotaxis and flocking
DESCRIPTION:Active Matter Seminar \nSpeaker: Ricard Alert\, Max Planck Institute for the Physics of Complex Systems \nTitle: Directed motion in active matter: Frictiotaxis and flocking \nAbstract: A key feature of active matter is its ability to move directionally\, both as individual particles and collectively. I will discuss two examples of directed motion: one in cell migration\, and one in collections of self-propelled colloids. First\, I will show that cells lacking cell-substrate adhesions migrate along friction gradients. We call this phenomenon frictiotaxis\, which is a new type of cell guidance. Second\, I will present a new mechanism for flocking whereby self-propelled particles can align and move collectively despite turning away from each other.
URL:https://cmsa.fas.harvard.edu/event/active-matter-22924/
LOCATION:CMSA Room G10\, CMSA\, 20 Garden Street\, Cambridge\, MA\, 02138\, United States
CATEGORIES:Active Matter Seminar
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/CMSA-Active-Matter-Seminar-02.29.2024.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240321T130000
DTEND;TZID=America/New_York:20240321T140000
DTSTAMP:20240318T140916Z
CREATED:20240314T184932Z
LAST-MODIFIED:20240318T140916Z
UID:10002912-1711026000-1711029600@cmsa.fas.harvard.edu
SUMMARY:Decoding The Origins of Fluidity in Multicellular Systems
DESCRIPTION:Active Matter Seminar \nSpeaker: Max Bi (Northeastern University) \nTitle: Decoding The Origins of Fluidity in Multicellular Systems \nAbstract: Organisms continually adapt to mechanical forces at the cellular and tissue levels\, a process crucial for sustaining vital life functions. In pivotal physiological processes\, such as cancer progression and embryonic development\, tissues are often poised near solid-like and fluid-like states. My talk will delve into three critical aspects of this phenomenon: (1) utilizing computational models that draw parallels with soft matter physics\, we examine shear-induced rigidity and the origins of fluidity in epithelial tissues; (2) exploring the intricate relationship between external mechanical stresses and internal cellular dynamics\, unraveling a range of rheological behaviors\, such as shear thinning and thickening\, which are key for understanding rheological responses in varying physical contexts; and (3) investigating how cellular processes like division and apoptosis influence tissue states\, with a specific focus on the emergence of hexatic phases\, an intermediate state exhibiting properties of both solids and liquids.
URL:https://cmsa.fas.harvard.edu/event/activematter-32124/
LOCATION:CMSA Room G10\, CMSA\, 20 Garden Street\, Cambridge\, MA\, 02138\, United States
CATEGORIES:Active Matter Seminar
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/CMSA-Active-Matter-Seminar-03.21.2024.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240404T130000
DTEND;TZID=America/New_York:20240404T140000
DTSTAMP:20240401T210220Z
CREATED:20240328T161543Z
LAST-MODIFIED:20240401T210220Z
UID:10003353-1712235600-1712239200@cmsa.fas.harvard.edu
SUMMARY:Shape morphing with swelling hydrogels and expanding foams
DESCRIPTION:Active Matter Seminar \nSpeaker: Abby Plummer\, Boston University \nTitle: Shape morphing with swelling hydrogels and expanding foams \nAbstract: Materials that increase in size offer intriguing possibilities for shape-morphing applications. Here\, we explore two such systems—swelling polyacrylamide hydrogels and expanding polyurethane foams. The hydrogels swell by absorbing water into crosslinked polymer networks. They can therefore be modeled by coupling solvent migration with the deformations of a hyperelastic solid. In contrast\, the foams initially behave as liquids with viscosity and volume increasing in time\, responding elastically only when close to solidification. We investigate how these expanding materials are sculpted by complex environments with obstacles and trenches.
URL:https://cmsa.fas.harvard.edu/event/active-matter-4424/
LOCATION:Hybrid – G10
CATEGORIES:Active Matter Seminar
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/CMSA-Active-Matter-Seminar-04.04.2024.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240502T133000
DTEND;TZID=America/New_York:20240502T143000
DTSTAMP:20240430T131929Z
CREATED:20240416T181909Z
LAST-MODIFIED:20240430T131929Z
UID:10003376-1714656600-1714660200@cmsa.fas.harvard.edu
SUMMARY:Non-dispersive one-way signal amplification in sonic metamaterials
DESCRIPTION:Active Matter Seminar \nSpeaker: Jayson Paulose\, University of Oregon \nTitle: Control of parametric amplification in space-time modulated mechanical metamaterials \nAbstract: Active mechanical metamaterials harbor acoustic signal processing functionalities that are impossible to achieve in passive structures. Amplifying an elastic wave as it passes through the material is a prominent example\, with potential applications in acoustic signal processing and loss mitigation. The fundamental mechanism for signal amplification of this kind is the parametric amplifier–an oscillator whose stiffness is periodically modulated in time\, which can inject energy into mechanical oscillations. Typically\, parametric amplification occurs at distinct modulation frequencies that are trivially related to the resonance modes of the unmodulated system\, which restricts its utility for amplifying signals with complex spatial or spectral structure. In this talk\, I’ll show how spatial variation of the modulation phase in parametric oscillator networks enables amplification phenomena that are far richer than those achievable by uncoupled and uncoordinated parametric amplifiers. Examples include turning off parametric resonances for particular vibrational modes in small assemblies [1]\, and achieving nonreciprocal broadband amplification in periodic arrays [2]. The existence of parametric resonances is tied to the internal symmetries inherent to mechanical systems as well as the symmetries obeyed by the parametric variation in space and time\, through an exact theoretical framework that augments the standard Floquet analysis of space-time modulated systems. \n  \n[1] Melkani and Paulose\, arXiv:2310.08734 \n[2] Kruss and Paulose\, PRApplied17\, 024020 (2022)
URL:https://cmsa.fas.harvard.edu/event/active-matter-5224/
LOCATION:Jefferson 256\, 17 Oxford Street\, Cambridge\, MA\, 02138\, United States
CATEGORIES:Active Matter Seminar
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/CMSA-Active-Matter-Seminar-05.02.2024-2.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240516T130000
DTEND;TZID=America/New_York:20240516T140000
DTSTAMP:20240510T175438Z
CREATED:20240416T181859Z
LAST-MODIFIED:20240510T175438Z
UID:10003377-1715864400-1715868000@cmsa.fas.harvard.edu
SUMMARY:Controlling chaotic advection in 2D active nematics
DESCRIPTION:Active Matter Seminar \nSpeaker: Kevin Mitchell\, University of California\, Merced \nTitle: Controlling chaotic advection in 2D active nematics \nAbstract: Recent years have seen a surge of interest in active materials\, in which energy injected at the microscale gives rise to mesoscale coherent motion. One prominent example is an active 2D “liquid crystal” composed of microtubules in the nematic phase. The activity is generated by molecular motors that consume ATP to generate local shearing between the microtubules. The resulting 2D fluid flow exhibits self-generated mesoscale chaotic dynamics with a characteristic folding and stretching pattern. We analyze this dynamics from the perspective of chaotic advection\, in which the fluid can be viewed as “stirred” by topological defects in the nematic order parameter. Typically\, these defects move in an irregular\, chaotic pattern. We explore conditions\, both theoretically and in experiments\, under which the topological defects can be coaxed to perform regular periodic motion\, thus bringing some degree of order to the chaos.
URL:https://cmsa.fas.harvard.edu/event/active-matter-51624/
LOCATION:CMSA Room G10\, CMSA\, 20 Garden Street\, Cambridge\, MA\, 02138\, United States
CATEGORIES:Active Matter Seminar
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/CMSA-Active-Matter-Seminar-05.16.2024.docx-1.png
END:VEVENT
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