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DTSTART;TZID=America/New_York:20220707T090000
DTEND;TZID=America/New_York:20220707T100000
DTSTAMP:20260407T011104
CREATED:20240215T094540Z
LAST-MODIFIED:20240229T085211Z
UID:10002727-1657184400-1657188000@cmsa.fas.harvard.edu
SUMMARY:The phenotype of the last universal common ancestor and the evolution of complexity
DESCRIPTION:Interdisciplinary Science Seminar\n\n\n\n\n\nSpeaker: Fouad El Baidouri\, Broad Institute \nTitle: The phenotype of the last universal common ancestor and the evolution of complexity \nAbstract: A fundamental concept in evolutionary theory is the last universal common ancestor (LUCA) from which all living organisms originated. While some authors have suggested a relatively complex LUCA it is still widely assumed that LUCA must have been a very simple cell and that life has subsequently increased in complexity through time. However\, while current thought does tend towards a general increase in complexity through time in Eukaryotes\, there is increasing evidence that bacteria and archaea have undergone considerable genome reduction during their evolution. This raises the surprising possibility that LUCA\, as the ancestor of bacteria and archaea may have been a considerably complex cell. While hypotheses regarding the phenotype of LUCA do exist\, all are founded on gene presence/absence. Yet\, despite recent attempts to link genes and phenotypic traits in prokaryotes\, it is still inherently difficult to predict phenotype based on the presence or absence of genes alone. In response to this\, we used Bayesian phylogenetic comparative methods to predict ancestral traits. Testing for robustness to horizontal gene transfer (HGT) we inferred the phenotypic traits of LUCA using two robust published phylogenetic trees and a dataset of 3\,128 bacterial and archaeal species. \nOur results depict LUCA as a far more complex cell than has previously been proposed\, challenging the evolutionary model of increased complexity through time in prokaryotes. Given current estimates for the emergence of LUCA we suggest that early life very rapidly evolved cellular complexity.
URL:https://cmsa.fas.harvard.edu/event/iss_7722/
CATEGORIES:Interdisciplinary Science Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20220707T103000
DTEND;TZID=America/New_York:20220707T123000
DTSTAMP:20260407T011104
CREATED:20240215T100432Z
LAST-MODIFIED:20240229T091815Z
UID:10002737-1657189800-1657197000@cmsa.fas.harvard.edu
SUMMARY:Anomalies\, dynamics and phases in strongly-coupled chiral gauge theories: Recent developments
DESCRIPTION:Speaker: Kenichi Konishi (UNIPI.IT) \nTitle: Anomalies\, dynamics and phases in strongly-coupled chiral gauge theories: Recent developments \nAbstract: After many years of efforts\, still very little is known today about the physics of strongly-coupled chiral gauge theories in four dimensions\, in spite of an important role they might play in the physics of fundamental interactions beyond the standard SU(3)xSU(2)xU(1) model. This is in stark contrast with the vectorlike gauge theories for which we have many solid results\, thanks to some exact theorems\, to the lattice simulation studies\, to the Seiberg-Witten exact solution of N=2 supersymmetric gauge theories\, and last\, but not the least\, to the real-world strong-interaction phenomenology and experimental tests of Quantum Chromodynamics. \nThe purpose of this seminar is to discuss the results of our recent efforts to improve the understanding of the strongly-coupled chiral gauge theories. Among the main tools of analysis are the consideration of anomalies. We use both the conventional ’t Hooft anomaly-matching ideas\, and new\, more stringent constraints coming from the generalized anomalies involving some higher-form symmetries. Also\, the so-called strong anomalies\, little considered in the context of chiral gage theories\, are found to carry significant implications. \nAs the playground we study several classes of SU(N) gauge theories\, the so-called Bars-Yankielowicz models\, the generalized Georgi-Glashow models\, as well as a few other simple theories with the fermions in complex\, anomaly-free representations of the color SU(N). \nColor-flavor-locked dynamical Higgs phase and dynamical Abelianization\, emerge\, among others\, as two particularly interesting possible phases the system can flow into in the infrared\, depending on the matter fermion content of the model.
URL:https://cmsa.fas.harvard.edu/event/qm_7722/
LOCATION:Virtual
CATEGORIES:Quantum Matter
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20220714T090000
DTEND;TZID=America/New_York:20220714T100000
DTSTAMP:20260407T011104
CREATED:20240214T091545Z
LAST-MODIFIED:20240301T101549Z
UID:10002614-1657789200-1657792800@cmsa.fas.harvard.edu
SUMMARY:Topological and geometrical aspects of spinors in insulating crystals
DESCRIPTION:Abstract:  Introducing internal degrees of freedom in the description of crystalline insulators has led to a myriad of theoretical and experimental advances. Of particular interest are the effects of periodic perturbations\, either in time or space\, as they considerably enrich the variety of electronic responses. Here\, we present a semiclassical approach to transport and accumulation of general spinor degrees of freedom in adiabatically driven\, weakly inhomogeneous crystals of dimensions one\, two and three under external electromagnetic fields. Our approach shows that spatio-temporal modulations of the system induce a spinor current and density that is related to geometrical and topological objects — the spinor-Chern fluxes and numbers — defined over the higher-dimensional phase-space of the system\, i.e.\, its combined momentum-position-time coordinates. \nThe results are available here: https://arxiv.org/abs/2203.14902 \nBio: Ioannis Petrides is a postdoctoral fellow at the School of Engineering and Applied Sciences at Harvard University. He received his Ph.D. from the Institute for Theoretical Physics at ETH Zurich. His research focuses on the topological and geometrical aspects of condensed matter systems.
URL:https://cmsa.fas.harvard.edu/event/7-14-2022-interdisciplinary-science-seminar/
CATEGORIES:Interdisciplinary Science Seminar
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/CMSA-Interdisciplinary-Science-Seminar-07.14.22-1583x2048-1.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20220721T090000
DTEND;TZID=America/New_York:20220721T100000
DTSTAMP:20260407T011104
CREATED:20240214T111802Z
LAST-MODIFIED:20240301T092042Z
UID:10002694-1658394000-1658397600@cmsa.fas.harvard.edu
SUMMARY:Infants’ sensory-motor cortices undergo microstructural tissue growth coupled with myelination
DESCRIPTION:Abstract: The establishment of neural circuitry during early infancy is critical for developing visual\, auditory\, and motor functions. However\, how cortical tissue develops postnatally is largely unknown. By combining T1 relaxation time from quantitative MRI and mean diffusivity (MD) from diffusion MRI\, we tracked cortical tissue development in infants across three timepoints (newborn\, 3 months\, and 6 months). Lower T1 and MD indicate higher microstructural tissue density and more developed cortex. Our data reveal three main findings: First\, primary sensory-motor areas (V1: visual\, A1: auditory\, S1: somatosensory\, M1: motor) have lower T1 and MD at birth than higher-level cortical areas. However\, all primary areas show significant reductions in T1 and MD in the first six months of life\, illustrating profound tissue growth after birth. Second\, significant reductions in T1 and MD from newborns to 6-month-olds occur in all visual areas of the ventral and dorsal visual streams. Strikingly\, this development was heterogenous across the visual hierarchies: Earlier areas are more developed with denser tissue at birth than higher-order areas\, but higher-order areas had faster rates of development. Finally\, analysis of transcriptomic gene data that compares gene expression in postnatal vs. prenatal tissue samples showed strong postnatal expression of genes associated with myelination\, synaptic signaling\, and dendritic processes. Our results indicate that these cellular processes may contribute to profound postnatal tissue growth in sensory cortices observed in our in-vivo measurements. We propose a novel principle of postnatal maturation of sensory systems: development of cortical tissue proceeds in a hierarchical manner\, enabling the lower-level areas to develop first to provide scaffolding for higher-order areas\, which begin to develop more rapidly following birth to perform complex computations for vision and audition. \nThis work is published here: https://www.nature.com/articles/s42003-021-02706-w
URL:https://cmsa.fas.harvard.edu/event/7-21-2022-interdisciplinary-science-seminar/
CATEGORIES:Interdisciplinary Science Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20220722T093000
DTEND;TZID=America/New_York:20220722T110000
DTSTAMP:20260407T011104
CREATED:20240216T093333Z
LAST-MODIFIED:20240216T093333Z
UID:10002762-1658482200-1658487600@cmsa.fas.harvard.edu
SUMMARY:7/22/2020 Quantum Matter Seminar
DESCRIPTION:
URL:https://cmsa.fas.harvard.edu/event/7-22-2020-quantum-matter-seminar/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20220728T090000
DTEND;TZID=America/New_York:20220728T100000
DTSTAMP:20260407T011104
CREATED:20240215T094315Z
LAST-MODIFIED:20240229T084527Z
UID:10002726-1658998800-1659002400@cmsa.fas.harvard.edu
SUMMARY:Statistical Mechanical theory for spatio-temporal evolution of Intra-tumor heterogeneity in cancers: Analysis of Multiregion sequencing data
DESCRIPTION:CMSA Interdisciplinary Science Seminar \nSpeaker: Sumit Sinha\, Harvard University \nTitle: Statistical Mechanical theory for spatio-temporal evolution of Intra-tumor heterogeneity in cancers: Analysis of Multiregion sequencing data (https://arxiv.org/abs/2202.10595) \nAbstract: Variations in characteristics from one region (sub-population) to another are commonly observed in complex systems\, such as glasses and a collection of cells. Such variations are manifestations of heterogeneity\, whose spatial and temporal behavior is hard to describe theoretically. In the context of cancer\, intra-tumor heterogeneity (ITH)\, characterized by cells with genetic and phenotypic variability that co-exist within a single tumor\, is often the cause of ineffective therapy and recurrence of cancer. Next-generation sequencing\, obtained by sampling multiple regions of a single tumor (multi-region sequencing\, M-Seq)\, has vividly demonstrated the pervasive nature of ITH\, raising the need for a theory that accounts for evolution of tumor heterogeneity. Here\, we develop a statistical mechanical theory to quantify ITH\, using the Hamming distance\, between genetic mutations in distinct regions within a single tumor. An analytic expression for ITH\, expressed in terms of cell division probability (α) and mutation probability (p)\, is validated using cellular-automaton type simulations. Application of the theory successfully captures ITH extracted from M-seq data in patients with exogenous cancers (melanoma and lung). The theory\, based on punctuated evolution at the early stages of the tumor followed by neutral evolution\, is accurate provided the spatial variation in the tumor mutation burden is not large. We show that there are substantial variations in ITH in distinct regions of a single solid tumor\, which supports the notion that distinct subclones could co-exist. The simulations show that there are substantial variations in the sub-populations\, with the ITH increasing as the distance between the regions increases. The analytical and simulation framework developed here could be used in the quantitative analyses of the experimental (M-Seq) data. More broadly\, our theory is likely to be useful in analyzing dynamic heterogeneity in complex systems such as supercooled liquids. \nBio: I am a postdoctoral fellow in Harvard SEAS (Applied Mathematics) and Dana Farber Cancer Institute (Data Science) beginning Feb 2022. I finished my PhD in Physics (Theoretical Biophysics) from UT Austin (Jan 2022) on “Theoretical and computational studies of growing tissue”.  I pursued my undergraduate degree in Physics from the Indian Institute of Technology\, Kanpur in India (2015). Boradly\, I am interested in developing theoretical models\, inspired from many-body statistical physics\, for biological processes at different length and time scales. \n 
URL:https://cmsa.fas.harvard.edu/event/iss_72822/
LOCATION:CMSA Room G10\, CMSA\, 20 Garden Street\, Cambridge\, MA\, 02138\, United States
CATEGORIES:Interdisciplinary Science Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20220730T090000
DTEND;TZID=America/New_York:20220801T134500
DTSTAMP:20260407T011104
CREATED:20230705T041718Z
LAST-MODIFIED:20250305T170940Z
UID:10000056-1659171600-1659361500@cmsa.fas.harvard.edu
SUMMARY:Advances in Mathematical Physics
DESCRIPTION:A Conference in Honor of Elliott H. Lieb on his 90th Birthday\nOn July 30 – Aug 1\, 2022 the Harvard Mathematics Department and the CMSA co-hosted a birthday conference in honor of Elliott Lieb. \nThis meeting highlights Elliott’s vast contribution to math and physics. Additionally\, this meeting features Prof. Lieb’s more recent impact in strong subadditivity of entropy and integrable systems (ice model\, Temperley-Lieb algebra etc.). \nVenue:\nJuly 30–31\, 2022: Hall B\, Science Center\, 1 Oxford Street\, Cambridge\, MA\, 02138\nAugust 1\, 2022: Hall C\, Science Center\, 1 Oxford Street\, Cambridge\, MA\, 02138 \nSchedule (pdf) \nOrganizers:\nMichael Aizenman\, Princeton University\nJoel Lebowitz\, Rutgers University\nRuedi Seiler\, Technische Universität Berlin\nHerbert Spohn\, Technical University of Munich\nHorng-Tzer Yau\, Harvard University\nShing-Tung Yau\, Harvard University\nJakob Yngvason\, University of Vienna \nSPEAKERS:\nRafael Benguria\, Pontificia Universidad Catolica de Chile\nEric Carlen\, Rutgers University\nPhilippe Di Francesco\, University of Illinois\nHugo Duminil-Copin\, IHES\nLászló Erdös\, Institute of Science and Technology Austria\nRupert Frank\, Ludwig Maximilian University of Munich\nJürg Fröhlich\, ETH Zurich\nAlessandro Giuliani\, Università degli Studi Roma Tre\nBertrand Halperin\, Harvard University\nKlaus Hepp\, Institute for Theoretical Physics\, ETH Zurich\nSabine Jansen\, Ludwig Maximilian University of Munich\nMathieu Lewin\, Université Paris-Dauphine\nBruno Nachtergaele\, The University of California\, Davis\nYoshiko Ogata\, University of Tokyo\nRon Peled\, Tel Aviv University\nBenjamin Schlein\, University of Zurich\nRobert Seiringer\, Institute of Science and Technology Austria\nJan Philip Solovej\, University of Copenhagen\nHal Tasaki\, Gakushuin University\nSimone Warzel\, Technical University of Munich\nJun Yin\, The University of California\, Los Angeles \n 
URL:https://cmsa.fas.harvard.edu/event/advances-in-mathematical-physics/
LOCATION:Harvard Science Center\, 1 Oxford Street\, Cambridge\, MA\, 02138
CATEGORIES:Conference,Event
ATTACH;FMTTYPE=image/png:https://cmsa.fas.harvard.edu/media/Elliott-Lieb-conference-2022_banner-2-1536x734-1.png
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