|
Speaker: Nicholas J. Magazine, Louisiana State UniversityTitle: 10/7/2021 Interdisciplinary Science SeminarVenue: VirtualTitle: SiRNA Targeting TCRb: A Proposed Therapy for the Treatment of Autoimmunity Abstract: As of 2018, the United States National Institutes of Health estimate that over half a billion people worldwide are affected by autoimmune disorders. Though these conditions are prevalent, treatment options remain relatively poor, relying primarily on various forms of immunosuppression which carry potentially severe side effects and often lose effectiveness over time. Given this, new forms of therapy are needed. To this end, we have developed methods for the creation of small-interfering RNA (siRNA) for hypervariable regions of the T-cell receptor β-chain gene (TCRb) as a highly targeted, novel means of therapy for the treatment of autoimmune disorders. This talk will review the general mechanism by which… |
|
Speaker: Michael Simkin, Harvard CMSATitle: 9/23/2021 Interdisciplinary Science SeminarVenue: VirtualTitle: The number of n-queens configurations Abstract: The n-queens problem is to determine Q(n), the number of ways to place n mutually non-threatening queens on an n x n board. The problem has a storied history and was studied by such eminent mathematicians as Gauss and Polya. The problem has also found applications in fields such as algorithm design and circuit development. Despite much study, until recently very little was known regarding the asymptotics of Q(n). We apply modern methods from probabilistic combinatorics to reduce understanding Q(n) to the study of a particular infinite-dimensional convex optimization problem. The chief implication is that (in an appropriate sense) for a~1.94, Q(n) is approximately (ne^(-a))^n. Furthermore, our methods allow us to… |
|
Speaker: Michael SimkinTitle: The number of n-queens configurationsVenue: virtualSpeaker: Michael Simkin, Harvard CMSA Title: The number of n-queens configurations Abstract: The n-queens problem is to determine Q(n), the number of ways to place n mutually non-threatening queens on an n x n board. The problem has a storied history and was studied by such eminent mathematicians as Gauss and Polya. The problem has also found applications in fields such as algorithm design and circuit development. Despite much study, until recently very little was known regarding the asymptotics of Q(n). We apply modern methods from probabilistic combinatorics to reduce understanding Q(n) to the study of a particular infinite-dimensional convex optimization problem. The chief implication is that (in an appropriate sense) for a~1.94, Q(n) is approximately (ne^(-a))^n. Furthermore, our… |
|
Speaker:Title: Moduli spaces of stable pairs on algebraic surfacesVenue: virtualInterdisciplinary Science Seminar Speaker: Yinbang Lin (Tongji University) Title: Moduli spaces of stable pairs on algebraic surfaces Abstract: As a variant of Grothendieck’s Quot schemes, we introduce the moduli space of limit stable pairs. We show an example over a smooth projective algebraic surface where there is a virtual fundamental class. We are able to describe this class explicitly. We will also show an application towards moduli of sheaves. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Speaker: Francis Lazarus, CNRS / Grenoble UniversityTitle: 1/13/2022 Interdisciplinary Science SeminarVenue: VirtualTitle: A universal triangulation for flat tori Abstract: A celebrated theorem of Nash completed by Kuiper implies that every smooth Riemannian surface has a C¹ isometric embedding in the Euclidean 3-space E³. An analogous result, due to Burago and Zalgaller, states that every polyhedral surface, obtained by gluing Euclidean triangles, has an isometric PL embedding in E³. In particular, this provides PL isometric embeddings for every flat torus (a quotient of E² by a rank 2 lattice). However, the proof of Burago and Zalgaller is partially constructive, relying on the Nash-Kuiper theorem. In practice, it produces PL embeddings with a huge number of vertices, moreover distinct for every flat torus. Based on a construction of Zalgaller and on… |