Attempts at understanding human axial elongation and patterning

2022-10-20 12:00 - 13:00
CMSA Room G10
Address: CMSA, 20 Garden Street, Cambridge, MA 02138 USA
Active Matter Seminar
Speaker: Sharad Ramanathan, Harvard
Title: Attempts at understanding human axial elongation and patterning
Abstract: Some of the most dramatic events during human development is the axial elongation of the embryo with concomitant changes in the geometry and composition of the underlying tissues. The posterior part of the embryo gives rise to the spinal cord, vertebral column, ribcage, back muscles, and dermis.  In this talk, I will present our attempts at coaxing human embryonic stem cells to form these structures of the early human embryo that closely recapitulate the geometry, relative arrangements, composition, and dynamics of development of the early spinal cord flanked progenitors of the musculoskeletal system. Our goal was to do so, such that we could build hundreds of these organoids at a time. I will also present preliminary results for the use of this system to understand key events during early human development through imaging and genetic perturbations.