Abstract: Conifold transitions are important algebraic geometric constructions that have been of special interests in mirror symmetry, transforming Calabi-Yau 3-folds between A- and B-models. In this talk, I will discuss the change of the quintic del Pezzo 3-fold (Fano 3-fold of index 2 and degree 5) under the conifold transition at the level of the bounded derived category of coherent sheaves. The nodal quintic del Pezzo 3-fold X has at most 3 nodes. I will construct a semiorthogonal decomposition for D^b(X) and in the case of 1-nodal X, detail the change of derived categories from its smoothing to its small resolution.